Further, the enhanced AHR in obesity could also be linked to increased production of adipokines such as TNF-α, IL6, IL-8, monocyte chemoattractant protein-1, complement proteins, acute phase moieties, leptins and adiponectins from adipocytes and adipose macrophages [6]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.