Finally, since IL-6 levels may be elevated in TRAPS [74], it has been hypothesized that tocilizumab, a humanized monoclonal antibody that binds specifically to both soluble and membrane-bound IL-6 receptors and inhibits IL-6 receptor-mediated signaling, may be an alternative treatment option. The gene discussed is IL6; the disease is TNF receptor 1-associated periodic fever syndrome.