In glioblastoma, cancer cells were found to secrete high concentrations of IL-8, which was further demonstrated to function as a key factor involved in tumor-induced permeability in vitro, and to signal to brain microvascular endothelial cells via CXCR2, promoting VE-cadherin cell–cell junction remodeling, and elevated permeability (61). The gene discussed is CXCR2; the disease is neoplasm.