Next, to reinforce the notion that the altered production of eicosanoids observed in leprosy patients results from an active modulation by the M. leprae infection, serum concentrations of PGE2, PGD2 and LTB4 in sera from BT and LL patients were measured at the conclusion of MDT and compared with the levels observed before treatment. The gene discussed is PTGDS; the disease is leprosy.