CTNNA1 and CTNNB1, which were the most highly differentially expressed proteins in cancers with GOF mutp53 compared to NE-GOF mutp53, are involved in cell-cell adhesion signaling and the WNT signaling pathway, which suggests that the β-catenin signaling pathway, including CTNNB1, is involved in increasing the metastatic properties of tumors with GOF mutp53. The gene discussed is CTNNB1; the disease is cancer.