AGT and triple-A syndrome: The major findings of the present study were that (1) the combination therapy with atorvastatin and amlodipine, but not each monotherapy, suppressed the AngII-induced AAA formation, (2) the combination therapy inhibited apoptosis, infiltration of inflammatory cells and activity of MMP in abdominal aortic tissues, (3) Rho-kinase activity was enhanced at the AAA lesion in humans and (4) experimental AAA tissues induced by Ang-II showed high Rho-kinase activity, and that it was attenuated by the combination therapy (Figure 9).