SCARB1 and fibrosis: SR-BI−/−apoE−/− mice develop spontaneous and SR-BI−/−apoE-hypomorphic mice develop high fat, high cholesterol diet-induced accelerated aortic sinus and occlusive coronary artery atherosclerosis that is accompanied by cardiac fibrosis and enlargement, cardiac conductance and function abnormalities and early death within weeks [10], [14], [21]–[23].