APOE and atherosclerosis: Using a BM transplantation approach, we now demonstrate that selective restoration of SR-BI expression in BM derived cells is able to protect otherwise SR-BI-deficient and apoE-hypomorphic mice from diet induced atherosclerosis in the aortic sinus and coronary arteries, and is able to reduce the extent of cardiac fibrosis and cardiac enlargement (as qualitatively assessed by the appearance of the hearts and quantified by the heart/body weight ratios).