Despite the elevated levels of IL-6, we did not find any difference in the tendency of macrophages from SR-BI expressing or deficient mice to form foam cells when challenged in vitro with AcLDL, suggesting that reduced foam cell formation most likely does not underlie the reduced atherosclerosis we observed in SR-BI+/+→SR-BI−/− compared to control SR-BI−/−→SR-BI−/− mice. The gene discussed is CACNA1A; the disease is atherosclerosis.