To determine the contribution of SR-BI in BM derived cells to the protection against aortic sinus and coronary artery atherosclerosis we tested if restoration of normal SR-BI expression in BM-derived cells by transplantation of SR-BI−/−apoE-hypomorphic mice with BM from SR-BI+/+apoE-hypomorphic donors (SR-BI+/+apoE-hypomorphic→SR-BI−/−apoE-hypomorphic) might affect the development of atherosclerosis in aortic sinus and coronary arteries. This evidence concerns the gene APOE and coronary atherosclerosis.