SR-BI/apoE double KO mice rapidly (within 6 weeks of age) develop occlusive coronary artery (CA) atherosclerosis and exhibit extensive myocardial fibrosis, ECG abnormalities, cardiac enlargement, reduced heart function (ejection fraction, contractility and relaxation) and early death [10], [21]–[23]. The gene discussed is APOE; the disease is atherosclerosis.