TOR1A and early-onset generalized limb-onset dystonia: The corticostriatal LTD is also impaired in our Dyt1 ΔGAG heterozygous KI male mice, and both LTD and motor deficits can be restored by trihexyphenidyl, an anticholinergic that is commonly used for DYT1 dystonia patients to release their dystonic symptoms [37].