In this case, we investigated the state of Tumor + COX-2 siRNA vs. Tumor state (CT comparison), and the state of Tumor + NS-398 vs. Tumor (NT comparison), in order to validate whether the NSAID model could reveal the differences of these two types of therapeutic inhibition as Denkert et al. [28] demonstrated in their study. This evidence concerns the gene PTGS2 and neoplasm.