EGFR and colonic neoplasm: We found out that under the combination inhibition, in average, breast tumor cell lines still possess relatively higher activities (> 1.4 fold) of Hedgehog-pathway (1.75 fold), EGFR-pathway (1.64 fold), JAK/STAT-pathway (1.49 fold), WNT-pathway (1.43 fold), compared to colon tumor cell lines; while compared to lung tumor cell lines, breast tumor cell lines possess relatively higher activities (> 1.4 fold) of JAK/STAT-pathway (1.67 fold), cell-cycle-pathway (1.59 fold), ERBB-pathway (1.5 fold).