NFKB1 and cancer: In fact, our results are consistent with a number of studies showing that: 1) mutant p53 expression correlates positively with NF-κB activity in cultured cancer cells [28]; 2) elevated expression of mutant p53 is associated with increased NF-κB activation in cancer tissues [29]; and 3) mutant p53 augments NF-κB activity by affecting both the strength and duration of NF-κB activation [30].