Results of the present study, for the first time comprehensively demonstrates that this novel monoketone (1) selectively targets RT-induced NFκB; (2) disrupts IR-induced NFκB-TNFα-NFκB feedback cycle and abrogates its associated maintenance of downstream pro-survival targets and NB cell survival as such; (4) attenuates NFκB-mediated TERT transcription, transactivation; (5) mitigates NFκB-dependent telomerase activation and clonal expansion; and (6) completely regressed NB in an in vivo setting and regulates IR-induced NFκB and TNFα in human NB xenograft. The gene discussed is TERT; the disease is neuroblastoma.