To that end, Kasinski and colleagues causally correlated the amount of EF24 required for the suppression of lung cancer A549 cell growth to its ability to prevent the nuclear translocation of p65 subunit of NFκB, to block IκB phosphorylation and its subsequent degradation, and to inhibit catalytic activity of the IKK protein complex [39]. This evidence concerns the gene RELA and lung carcinoma.