We evaluated this by transfecting PC3-M and DU-145 human PCa cells with endoglin, along with siRNA specific to individual RII subtypes: activin A receptor type IIA (ActRIIA), activin A receptor type IIB (ActRIIB), bone morphogenetic protein receptor type II (BMPRII), or transforming growth factor β receptor type II (TGFβRII). The gene discussed is ACVR2A; the disease is posterior cortical atrophy.