Finally, within the Mts-4 interval on chromosome 18 (Table 1) resides Smad2 (SMAD family member 2/mothers against decapentaplegic homolog 2, 73.18 Mb), a signaling protein whose phosphorylation mediates TGF-beta induced breast cancer invasiveness [37], [38]. The gene discussed is SMAD2; the disease is breast cancer.