SNP-tagged haplotypes of neuropeptide S receptor 1 (NPSR1; also known as G-protein-coupled receptor for asthma susceptibility, GPRA or GPRA154) have been found to be associated with increased serum IgE levels or asthma, and have been functionally evaluated to be distinctively distributed between protein isoforms in bronchial biopsies from healthy and asthmatic subjects [32]. The gene discussed is NPSR1; the disease is asthma.