SORT1 and coronary artery disorder: Out of the 8 CAD susceptibility gene variants displaying significant association with circulating lipid species concentrations, 3 have not yet been previously reported to be involved in lipid metabolism (WDR12, ZC3HC1 and PHACTR1) and 3 are only known to affect lipoproteins levels (LPA, SORT1 and the ZNF259/APOA5-A4-C3-A1 gene region) [13], [28].