Carriers of the PEMT/RASD1/SMCR3 CAD risk allele had reduced level of the CVD-protective lipid specie LPC16∶0 (P = 0.031) as well as carriers of the PPAP2B CAD risk allele but the later association was only borderline significant (P = 0.056). The gene discussed is RASD1; the disease is coronary artery disorder.