Although men exposed to high androgens during the fetal life, have different presentations after puberty, possibly explained by different types of androgens resulting from the mentioned early [25,29,30], another reason is because the placenta converts the androgen to estrogen via aromatase enzyme [1] probably, in sons of women with polycystic ovary syndrome the amount of androgen metabolized by placenta, while the male fetus with congenital adrenal hyperplasia, fetus is exposed to androgen, directly, during fetal life. This evidence concerns the gene CYP19A1 and polycystic ovary syndrome.