Recent genomic profiling towards this aim in SCLC have uncovered thousands of mutations and deletions, occurring in multiple tumour suppressor pathways (eg. TP53, RB1, PTEN, EPHA7), and genes involved in chromatin modification (eg. CREBBP, MLL), as well as amplifications in putative SCLC cancer driver genes, such as SOX2[5], [8]. The gene discussed is RB1; the disease is small cell lung carcinoma.