This study demonstrates that in addition to the known roles of HPV16 oncoproteins [31], these oncoproteins promote invasiveness of cervical cancer cells through transcriptional upregulation of both MMP-2 and MT1-MMP and a combination of HPV16 oncoproteins significantly stimulates MMP-2 and MT1-MMP expression and cell invasion more than individual 16E6F, 16E6*I or 16E7. Here, MMP2 is linked to cervical cancer.