TMPRSS3, MYO15A, GJB2, SLC26A4 were found to be responsible for deafness in autosomal recessive or sporadic families, while TECTA, WFS1, MYH9, EYA1, COL4A5 and COL11A1 were identified as the responsible genes for deafness in autosomal dominant families. The gene discussed is TMPRSS3; the disease is deafness.