MMP8 and heart failure: However, when adjusted for major baseline characteristics (age, gender, body mass index, history of hypertension, diabetes mellitus, prior angina, reperfusion therapy, heart failure during hospitalization, final TIMI flow grade in the infarct-related vessel, systolic blood pressure, heart rate, creatine kinase levels, wall motion score index and LVEF), MMP-8 was the only MMP that remained significantly associated with clinical outcome (P = 0.02) while MMP-2 and MMP-9 did not reach statistical significance (P = 0.327 and 0.311, respectively).