IRF1 and cancer: Our search results of these genes against Cscan database [38] indicate that 28 of these genes are regulated directly by nine proto-oncogenes, namely BCL3, ETS1, FOS, JUN, MXI1, MYC, PAX5, SPI1 and TAL1; and 17 genes are regulated by two tumor-suppressors, IRF1 and BRCA1 as shown in Figure 4, indicating that there is a strong connection between deacidification and cancer growth.