Limitations in human subjects, tissue availability, and cell yield precluded analysis of all aspects of lipid metabolism including the effects of known mediators of lipolysis and FAO in the context of hypoxia, such as insulin, adiponectin, and other stimuli, as well as rigorous correlation of in vitro results with clinical characteristics such as the presence of metabolic disease. The gene discussed is ADIPOQ; the disease is Other metabolic disease.