For PTGS2 rs5275, sensitivity analyses indicated that inclusion of the independent study by Lurie et al. [7] was primarily responsible for the significant difference observed in the risk of cancer development between NSAID users and non-NSAID users homozygous for the major allele in the overall group, cancer subgroups other than colon cancer, and the USA subgroup. Here, PTGS2 is linked to colonic neoplasm.