NOS3 and thanatophoric dysplasia: Furthermore, our research team had found many genetic markers for TD, including dopamine D1 [24],D2 [33], [35], D3 and brain-derived neurotrophic factor [38], melatonin receptor [25], beta-arrestin [28], regulators of G-protein signaling [30],Par-4 [31], N-methyl-D-aspartate receptor [34], endothelial nitric oxide synthase [36], hratioquinone oxidoreductase [37], cytochrome P-450 2D6 [40],and neural nitric oxide synthase gene [41].