In our study here, we tried to establish if there is any correlation between hemichannel (connexon) instability and defective functionality of Cx26 in point mutations, in TM4, that are found to be responsible for cases of NSHL [16]–[18], [20], [32], [34], [40]–[43]. This evidence concerns the gene GJB2 and nodular sclerosis classical Hodgkin lymphoma.