CPT2 and obesity due to melanocortin 4 receptor deficiency: Dysfunction of this individual component is well known in human metabolic disease, thus cPT1 knockout mice model is used a model for obesity and inborn errors of mitochondrial β-oxidation [28], [29], whereas, defective complex I and complex V is a signature of neurological diseases such as Parkinson's and Alzheimer's [21], [30].