Although the current correlative studies were not designed to precisely characterize the functional changes associated with increased IRF8 expression, increased WT-IRF8 expression was significantly associated with FAB M5 AML (i.e., monocytic leukemia), which is consistent with previous ex vivo studies examining the functional impact of over-expression of WT-IRF8[5], [26], [27]. This evidence concerns the gene IRF8 and monocytic leukemia.