LRRK2 and Parkinson disease: Coding changes causative for PD are located within the enzymatic core of LRRK2, namely the ROC-COR-Kinase triad of domains, and several of the mutations described in this region disrupt the enzymatic activities of the protein – strongly implicating the enzymatic function of LRRK2 in the pathogenesis of PD [9]–[11].