Therefore, within the scope of the present study was investigation of the role of AR-related pathways, major components of the sympathoadrenal response to stress and targets of drugs used for the treatment of hypertension, asthma, angina pectoris, congestive heart failure, cardiac arrhythmias, prostatic hypertrophy, glaucoma, and depression [34], [35]. This evidence concerns the gene AR and major depressive disorder.