And we found SP and ALDHBr overlapping population was the highest CSCs/CICs enriched population which exhibited higher sphere formation, higher tumor-initiation, higher adipocyte differentiation ability, higher drug resistance and higher expression level of SOX2, a representative marker of CSCs/CICs, which is related to the tumor-initiating ability of CSCs/CICs [26]. This evidence concerns the gene SOX2 and neoplasm.