On the other hand, recent studies on cardiovascular diseases have implicated that upregulation of a specific arginase isoform in the vasculature may contribute to the development of vascular disease linked to l-arginine deficiency and reduced NO production (34, 35), especially under conditions with elevated level of angiotensin II (Ang II), hypertension, and inflammation, all of which are closely associated with oxidative stress (36). This evidence concerns the gene AGT and hypertensive disorder.