In the animal model of genetic (67, 68) or metabolic (69) form of hypertension, chronic inhibition of arginase was recently shown to improve endothelium-dependent vascular function (67–, 69), reduce cardiac fibrosis (68), prevent vascular remodeling and Arg-I overexpression (68), inhibit insulin-resistance (69), reduce oxidative stress (69), and alleviate hypertension (67–, 69). This evidence concerns the gene LNCARGI and hypertensive disorder.