In addition, Tax-1 is a key player in immortalization and transformation of infected T cells by enhancing the transcriptional expression of genes that control T cell proliferation, affecting genes involved in mitotic checkpoints and further inactivating tumor suppressor pathways (Peloponese et al., 2007; Boxus et al., 2008; Journo et al., 2009; Chlichlia and Khazaie, 2010). Here, CNTN2 is linked to neoplasm.