Abnormal or hyper-phosphorylated tau protein can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the development of Alzheimer’s disease and other diseases (such as TBI, Pick’s disease, corticobasal degeneration, frontotemporal dementia, and supranuclear palsy) (20). Here, MAPT is linked to frontotemporal dementia.