In subsequent studies we showed that the cytosolic AD abnormally hyperphosphorylated tau (AD P-tau) sequestered some of the normal tau and sedimented at 200,000 × g, whereas most of the non-hyperphosphorylated tau from the same AD brains remained in the 200,000 × g supernatant (8, 9). Here, MAPT is linked to Alzheimer disease.