In addition to SGLT-generated glucose uptake, radiation-induced electrosignaling via transient receptor potential melastatin 2 (TRPM2) and vanilloid 1 (TRPV1) cation channels, has been shown to stimulate Ataxia telangiectasia mutated (ATM) kinase activation, histone 2AX (H2AX) phosphorylation, and γH2AX focus formation in A549 lung adenocarcinoma cells, processes required to recruit further repair proteins to the DNA double strand break (Masumoto et al., 2013). Here, TRPM2 is linked to lung adenocarcinoma.