Alternatively, because leptin receptors are expressed on VTA neurons that show a dense set of projections to the extended central amygdala (Leshan et al., 2010), it might also be feasible that increased sensitivity to leptin during the SD winter months more strongly activates activity in the central nucleus of the amygdala thereby resulting in anxiety-like behaviors (Hunter et al., 2007). The gene discussed is LEP; the disease is Anxiety.