The tentative answer is yes, because almost every ChIP-seq study of TCF/LEF binding in cancer genomes, and one study of β-catenin–binding to the colon cancer genome, has identified the closely related, ATF-friendly, AP1 response element as a top, cosegregating motif (Figure 1E; [22]–[25], [26]). The gene discussed is HNF4A; the disease is cancer.