Measurement of bioluminescence (Figure 5B) allowed quantification of parasite burdens and demonstrated a significant increase in parasite growth at days 6 and 8 post-infection (day 6 p = 0.017, day 8 p = 0.005) in L-NAME treated as opposed to non-treated MKP-2+/+ mice (Figure 5C). The gene discussed is DUSP4; the disease is infection.