Treatment of LPS/IFN–γ activated MKP-2−/− and MKP-2+/+ macrophages with L-NAME partially ablated their ability to control parasite replication at 24 hours and totally ablated their ability to control parasite growth through 48 hours and 72 hours post-infection (p<0.0001) (Figure 7A). Here, DUSP4 is linked to infection.