Conversely, treatment of LPS/IFN-γ activated MKP-2−/− and MKP-2+/+ macrophages with nor-NOHA partially ablated their ability to control parasite growth at 24 hours (MKP-2+/+ p = 0.005 and MKP-2−/− p = 0.006 respectively) but not at 48 or 72 hours post-infection (Figure 7A). The gene discussed is DUSP4; the disease is infection.