In response to tumor-associated migration inhibitory factor (MIF), interleukin-8 (IL-8), and plasminogen activator inhibitor-1 (PAI-1), astrocytes release various inflammatory cytokines including IL-1β, TNF-α, and IL-6, all of which have been shown to promote tumor cell proliferation in vitro [38–42]. The gene discussed is SERPINE1; the disease is neoplasm.