Chan and colleagues, who investigated the influence of CRP, Interleukin-6 (IL-6) and Soluble Tumor Necrosis Factor Receptor 2 (TNFR-2, a TNF-α receptor superfamily member) in CRC, in a cohort of 33,000 women, found an increased risk of CRC in woman having high levels of sTNFR-2 (p = 0.03), but found no correlation with the other two markers [124]. This evidence concerns the gene IL6 and colorectal carcinoma.