BRAF and colorectal carcinoma: Imamura and colleagues reinforced this hypothesis by confirming that the respective malignancy of the codon 12 and 13 mutations is independent of the BRAF mutations that are often associated with a poorer CRC prognosis: even after eliminating BRAF as a confounding factor, codon 12 mutations were implicated in significantly higher colorectal cancer specific mortality codon 13 mutations [31].