AMPK is a cellular energy balance status sensor, and plays a role in the regulation of cell proliferation and growth through the inhibition of the mTOR pathway and activation of the CDKN1A (p21) pathway and p53. Increased expression of phosphorylated-AMPK is associated with a good prognosis among p-ERK-activated CRC patients [33]. This evidence concerns the gene CDKN1A and colorectal carcinoma.