FANCD2 and neoplasm: To confirm that ΔNp63 elevation results from an inactivated FANCD2, not from the off-target effect of FANCL silencing, we detected ΔNp63 expression in stably-transfected cell pairs derived from the HTB-4 bladder cancer cell line, in which the impaired FA pathway was induced by a high expression level of FAVL (a variant of FANCL that acts as a tumor promotion factor by inactivating FANCD2) [17, 18].