An elevated expression of mdig has been observed in some human cancers, including lung cancer [2], colon cancer [5], esophageal squamous cell carcinoma [6], gingival squamous cell carcinoma [7], lymphoma [8], renal cell carcinoma [9], neuroblastoma[10], gastric cancer[11], hepatocellular carcinoma[12], and cholangiocarcinoma [13]. Here, RIOX2 is linked to cancer.