Furthermore, since there are observations indicating a H3K9me3 dependency in the repression of the key stemness genes, most notably the Oct3/4, Nanog and Sox2 that are silenced in differentiated cells [40, 41], the activation or overexpression of mdig may provide a favorable scenario for reprogramming the somatic cells into stem cells or cancer stem cells. This evidence concerns the gene RIOX2 and cancer.