PDCD4 and glioblastoma: In accordance with this, other than U343 cells, we find that the levels of Bcl-xL mRNA do not differ significantly between HEK293 and GBM cells (Figure 2B), lending further support to the notion that PDCD4 is an inhibitor of Bcl-xL translation and that the loss of PDCD4 in GBM results in de-repression of Bcl-xL translation.