Interestingly, the enhanced use of tRNAIleUAU by EHDV2-IBA may confer an advantage to its replication process, as tRNAIleUAU was unique among other tRNAs in its sensitivity to stimulation of cells with IFN-β and IFN-γ, an integral part of the cellular response to infection (23). This evidence concerns the gene IFNG and infection.