Variants of KCNJ10 have also been considered as a risk factor for seizure susceptibility in genetic association studies [27] and biallelic mutations in KCNJ10 in humans are known to cause a syndromic form of hearing loss, EAST syndrome (epilepsy, ataxia, sensorineural deafness and renal tubulopathy) [28]. This evidence concerns the gene KCNJ10 and epilepsy.