The lack of a significant increase in total IL-10 protein release from Con A + ES stimulated cultures compared to those stimulated with Con A alone may be explained by the observation that throughout the infection study, Con A + ES-stimulated cultures proliferated and therefore expanded to a lesser extent than those cultured with Con A without ES, and therefore produced relatively more IL-10 per cell than non-ES stimulated cultures. The gene discussed is IL10; the disease is infection.