Exposure of PBMCs to L-NMMA, a competitive inhibitor of NOS, before incubation with egcSEs or SEA induced a significant decrease in tumor cell cytotoxicity of all supernatants (range: p = 0.01 for SEA to p = 0001 for SEO) with the sole exception of SEN (p = 0.85) (Figure 5). Here, NOS2 is linked to neoplasm.