AD is characterized pathologically by the presence of insoluble plaques and tangles composed of beta-amyloid (Aβ) formed by sequential amyloid precursor protein (APP) proteolysis and hyperphosphorlyated Tau (pTau) proteins (Hardy and Allsop, 1991; Walsh and Selkoe, 2004; Cole and Vassar, 2008). This evidence concerns the gene APP and Alzheimer disease.