IKBKB and Insulin resistance: Given that IKKβ is a key downstream mediator of insulin resistance and its blockade by salicylates attenuated hyperglycemia, hyperinsulinemia, and dyslipidemia in obese rodents (130, 131), Hundal et al. asked whether high-dose aspirin (∼7 g/day) could ameliorate insulin resistance and improve glucose tolerance in patients with type 2 diabetes (132).