Sirtuin 1 (SIRT1), the mammalian homolog of yeast silent information-regulator 2 (Sir2), is an NAD+-dependent histone deacetylase that has been implicated in the regulation of lifespan under calorie restriction (95) or energy metabolism during fasting (96); thus, it is believed to be a promising target for type 2 diabetes (95, 97). Here, SIRT2 is linked to type 2 diabetes mellitus.