These results all suggest that the MCP-1-CCR2 signaling pathway plays an important role in adipose tissue inflammation (17, –19, 29, 30, 36), hepatic steatosis (17, 18, 37, 38), and glucose metabolism (17, –19, 29, 30, 36, –38) in insulin-resistant model mice. This evidence concerns the gene CCL2 and Hepatic steatosis.