The deterioration in βAR function and subsequent cAMP generation (Davinelli et al., 2012) is a common factor underlying hypertension, atherosclerosis, vascular insufficiency, and orthostatic hypotension, all conditions associated to important morbidity and mortality (Santulli, 2012a; Vu et al., 2012). Here, ADRB2 is linked to Hypertension.